• Studies are looking at the role of adjuvant chemotherapy with Adriamycin , mitoxantrone , cisplatin ,
Cytoxan , carboplatin , ifosfamide or progestational hormones in various doses and regimens.
Stage IVb
Distant metastases, intra-abdominal spread or disease in the lymph nodes of the groin.
Standard Treatment Treatment is based on the location of the distant metastasis , with the most common sites being the lungs or liver. Therapy is rarely curative and is usually palliative .
There is a 20 to 30 percent response rate to progestational hormones. If the metastatic cancer or the initial uterine tumor is sensitive to progestational hormones, as shown by the number of progesterone receptors it contains, then the response rate to hormone therapy will be significantly higher. The most commonly used progestational agent is Megace . Similarly, if the tumor contains many estrogen receptors, then antiestrogen therapy with tamoxifen may be effective with a response rate of 20 to 30 percent. Sometimes the two hormones are used together.
Chemotherapy with cisplatin + Adriamycin + Cytoxan every three to four weeks has been shown to be effective in some patients, with response rates in the range of 30 percent.
